Microtubule/Tubulin
Microtubules (micro- + tube + -ule) are a component of the cytoskeleton, found throughout the cytoplasm. They are found in eukaryotic cells, as well as some bacteria, and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin.
Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella.They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organelles, and intracellular macromolecular assemblies. They are also involved in chromosome separation, and are the major constituents of mitotic spindles, which are used to pull apart eukaryotic chromosomes.
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Docetaxel, a cytotoxic antimicrotuble agent, is frequently administrated as a first line treatment for prostate cancers. Docetaxel，一种紫杉醇类似物，通过结合到稳定的微管来抑制微管解聚。
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ABT-751(E 7010)是新型的生物相容性的微管蛋白结合剂和抗有丝分裂磺胺类化合物，对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。
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Vinorelbine ditartrate (长春瑞滨双酒石酸盐; KW-2307) 是抗有丝分裂剂，能抑制Hela细胞增殖，IC50为1.25 nM。
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CW-069是微管动力蛋白HSET变构抑制剂，比对KSP的抑制性高；W069 是一种变构选择性microtubule motor protein HSET抑制剂，IC50为75 μM, 其选择性显著高于KSP.
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CK-636 是一种Arp2/3 复合抑制剂，其IC50 为4 μM,在24 μM 和 32 μM时，分别能够抑制人的肌动蛋白聚合诱导和裂殖酵母与bovine Arp2/3的复合物。
More
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Docetaxel, a cytotoxic antimicrotuble agent, is frequently administrated as a first line treatment for prostate cancers. Docetaxel，一种紫杉醇类似物，通过结合到稳定的微管来抑制微管解聚。
More
-
ABT-751(E 7010)是新型的生物相容性的微管蛋白结合剂和抗有丝分裂磺胺类化合物，对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。
More
-
Vinorelbine ditartrate (长春瑞滨双酒石酸盐; KW-2307) 是抗有丝分裂剂，能抑制Hela细胞增殖，IC50为1.25 nM。
More
-
CW-069是微管动力蛋白HSET变构抑制剂，比对KSP的抑制性高；W069 是一种变构选择性microtubule motor protein HSET抑制剂，IC50为75 μM, 其选择性显著高于KSP.
More
-
CK-636 是一种Arp2/3 复合抑制剂，其IC50 为4 μM,在24 μM 和 32 μM时，分别能够抑制人的肌动蛋白聚合诱导和裂殖酵母与bovine Arp2/3的复合物。
More
